Trial results for a study investigating a dyadic approach for a remote physical activity intervention in adults with Alzheimer's Disease and their caregivers were posted on ClinicalTrials.gov on 2025-06-08, with 198 participants enrolled.
Background
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that impacts memory, thinking, and behavior, significantly affecting both patients and their caregivers. Maintaining physical activity is recognized as beneficial for overall health and cognitive function, even in the presence of AD. However, facilitating consistent physical activity can be challenging for individuals with AD, often requiring significant support. Caregivers of individuals with AD also face substantial physical and emotional demands, making their own well-being, including physical activity, an important consideration. Remote interventions offer a potential solution to overcome barriers to participation, such as transportation or scheduling conflicts, for both patients and caregivers.
Trial design
This completed study, designated as Phase NA, enrolled 198 participants (dyads of adults with AD and their caregivers) to investigate interventions for Alzheimer Disease. The objective was to compare the effectiveness of two intervention delivery strategies over 18 months: real-time group video conferencing (RGV) and enhanced usual care (EUC). The primary outcome aimed to compare total moderate physical activity (MPA) in adults with AD from baseline to 6 months, assessed using ActiGraph.
Key results
The trial reported several key measurements for moderate physical activity (MPA) in minutes per day:
- Real-time Group Video: Alzheimer's Patient:
- A mean MPA of 13.3 (Standard Deviation 13.2) minutes per day was observed.
- Another mean MPA of 14.7 (Standard Deviation 16.5) minutes per day was observed.
- A third mean MPA of 11.6 (Standard Deviation 12.9) minutes per day was observed.
- Real-time Group Video: Caregiver:
- A mean MPA of 20.7 (Standard Deviation 17.5) minutes per day was observed.
- Another mean MPA of 25.1 (Standard Deviation 23.2) minutes per day was observed.
- A third mean MPA of 22.6 (Standard Deviation 21.1) minutes per day was observed.
- Enhanced Usual Care: Alzheimer's Patient:
- A mean MPA of 14.4 (Standard Deviation 17.3) minutes per day was observed.
- Another mean MPA of 11.7 (Standard Deviation 14.2) minutes per day was observed.
- A third mean MPA of 14.1 (Standard Deviation 17.7) minutes per day was observed.
- Enhanced Usual Care: Caregiver:
- A mean MPA of 19.3 (Standard Deviation 19.5) minutes per day was observed.
- Another mean MPA of 23.7 (Standard Deviation 21.9) minutes per day was observed.
- A third mean MPA of 21.1 (Standard Deviation 21.5) minutes per day was observed.
What this means
The posted results provide specific mean values for moderate physical activity (MPA) in minutes per day for both Alzheimer's Disease patients and their caregivers across two intervention groups. While these measurements offer insights into the physical activity levels observed in the study participants, the data as presented does not include comparative analyses or statistical significance between the real-time group video conferencing and enhanced usual care arms. Therefore, these results contribute to understanding the observed physical activity levels in this population under different remote intervention strategies, setting a foundation for further analysis or future research.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT04102514, titled "A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers", were posted on 2025-06-08 on clinicaltrials.gov.