Trial results for 'Safety in Dementia': An Online Caregiver Intervention for Alzheimer's Disease were posted on ClinicalTrials.gov on 2026-05-14, showing an improvement of up to 5.1 points in caregiver preparation for decision making.
Background
Alzheimer's Disease is a progressive neurodegenerative disorder that impacts memory, thinking, and behavior, placing significant demands on informal caregivers. These caregivers often face complex decisions regarding patient safety, daily care, and long-term planning, which can be particularly challenging when managing individuals with dementia who have access to firearms, as noted in the trial's brief summary. Providing effective support and resources to enhance caregivers' preparedness for these critical decisions is essential for improving both caregiver well-being and patient safety outcomes.
Trial design
This completed study, designated as Phase NA, enrolled 500 participants, focusing on Caregivers, Decision Making, Alzheimer Disease, Social Media, and Safety. The trial was an online randomized study designed to recruit informal caregivers of community-dwelling adults with dementia who have firearm access. Participants were randomized into either the 'Safety in Dementia' intervention group or a 'Web Control' group. The specific primary outcomes were not detailed in the provided data.
Key results
The trial reported key measurements related to caregiver preparedness and self-efficacy:
- Preparation for Decision Making (score on a scale):
- For the 'Web Control' group, mean scores were 64.8 (Standard Deviation 26.9), 69.7 (Standard Deviation 24.9), 72.7 (Standard Deviation 24.3), and 75.7 (Standard Deviation 22.6).
- For the 'Safety in Dementia' group, mean scores were 69.8 (Standard Deviation 22.0), 73.7 (Standard Deviation 19.5), 77.8 (Standard Deviation 19.2), and 77.5 (Standard Deviation 21.5).
- Decision Self-Efficacy (score on a scale):
- For the 'Web Control' group, mean scores were 82.5 (Standard Deviation 19.0) and 83.3 (Standard Deviation 17.4).
- For the 'Safety in Dementia' group, mean scores were 79.6 (Standard Deviation 18.5) and 82.8 (Standard Deviation 15.4).
What this means
The results indicate that the 'Safety in Dementia' online intervention may enhance caregivers' preparation for decision making. The intervention group consistently showed higher mean scores for 'Preparation for Decision Making' compared to the 'Web Control' group across multiple measurements, with a maximum difference of 5.1 points. While 'Decision Self-Efficacy' scores were broadly comparable between the groups, the observed improvement in 'Preparation for Decision Making' suggests that this online intervention could be a valuable tool for supporting caregivers of individuals with Alzheimer's Disease, particularly in navigating complex safety-related decisions. Further analysis would be needed to determine statistical significance.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05173922, titled "Safety in Dementia": An Online Caregiver Intervention, were posted on 2026-05-14 on clinicaltrials.gov.