Periodontal Inflammation and Epigenetics in Obese Individuals

Part of paid clinical trials in New Orleans, Louisiana.

Sponsor
Louisiana State University Health Sciences Center in New Orleans
Study ID
NCT07610902
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Non-surgical periodontal therapy will be administered — PROCEDURE
    Non-surgical periodontal therapy (Deep cleaning-SRP): The deep cleaning by a scaling and root planing (SRP) procedure, is the standard initial treatment for all individuals diagnosed with periodontitis (periodontal disease). At the initial treatment planning appointment, each subject will receive intra-oral and extra-oral examination along with full mouth examination of the periodontal status, followed by diagnosis and treatment planning. The subject will then be scheduled for a deep cleaning procedure. The Deep cleaning procedure are carried out using hand instruments and ultrasonic instruments.

Study Details

The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are: • To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.

Key Dates

Start date
May 25, 2026
Status verified
May 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: non-obese with periodontitis
    Non-surgical periodontal therapy will be administered
  • Active Comparator: obese with periodontitis
    Non-surgical periodontal therapy will be administered

Primary Outcome Measure

Host-specific epigenetic signatures [ Time Frame: Baseline/Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
LSU Health Science Centre, School of DentistryNew OrleansLouisiana70119
Vinayak M Joshi, PhD, MS
[email protected]
15049418280
Jeanne St.Germain, RDH, B.S.
[email protected]
504-941-8276

Find similar trials in New Orleans, LA

By condition
Obesity / overweight
By specialty
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By research site
LSU Health Science Centre, School of Dentistry· New Orleans, LA

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