The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology

Part of paid clinical trials in Baton Rouge, Louisiana.

Sponsor
Pennington Biomedical Research Center
Study ID
NCT06059651
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
35 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Metabolic & Bariatric Surgery — PROCEDURE
    Roux-en-Y metabolic and bariatric surgery

Study Details

This study aims to determine the relationship between lipid kinetics changes and blood immunosuppressive cells by metabolic surgery in two patient cohorts.

Key Dates

Start date
Jan 1, 2024
Status verified
Feb 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Cohort 1
    Cohort #1 (within-subject) will enroll up to 10 women with class III obesity who plan to undergo Roux-en-Y metabolic and bariatric surgery as a standard of obesity care. Subjects will complete study measures preoperatively and one year postoperatively.
  • Arm: Cohort 2
    Cohort #2 (between-subject) will enroll up to 10 women with a history of class III obesity who underwent Roux-en-Y metabolic and bariatric surgery as a standard of obesity care approximately one year before enrollment. Subjects in this cohort will be matched on demographic and clinical variables to those in Cohort #1.

Primary Outcome Measure

Change in insulin-inhibited adipose tissue lipolysis [ Time Frame: Baseline, week 52 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Pennington Biomedical Resarch CenterBaton RougeLouisiana70808
Justin Brown

Find similar trials in Baton Rouge, LA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Pennington Biomedical Resarch Center· Baton Rouge, LA

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