Sleep and Performance

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT07608614
Status
Recruiting
Apply to this trial

Conditions

  • Glymphatic System
  • Sleep

Eligibility Criteria

Sex
ALL
Age
18 Years - 30 Years
Healthy Volunteers
Accepted

Interventions

  • Transcranial Electric Stimulation — DEVICE
    Participants will wear the Wireless Interface Sensor Pod (WISP), which combines EEG with Transcranial Electrical Stimulation (TES)
  • Sham Comparator — DEVICE
    Participants will wear the WISP device, but no TES

Study Details

This research is being done to apply new, contrast-free MRI (Magnetic Resonance Imaging) methods to understand the brain's waste clearance system (the "glymphatic" system) in younger adults. The Investigators hope the study will show how the different brain regions are involved in maintaining memories and how poor sleep affects these regions and our ability to remember. The Investigators will test whether the Wireless Interface Sensor Pod (WISP) improves brain function after poor sleep. The WISP is a headband that combines tracking brain waves and transcranial electrical stimulation (TES) to monitor and improve slow wave sleep and glymphatic clearance. IParticipants will be asked to: * Complete 4 in-person study visits (1 per week) over 4 weeks at the Diagnostic Imaging Sciences Center (DISC), located at the University of Washington Medical Center at Montlake, Seattle. Each visit will last 2 hours and includes a 1 hour MRI and 1 hour of cognitive testing. * Complete a daily journal about sleep, daily habits, etc. * The night before each of the four study visits, participants will sleep while wearing the WISP headband. * For two of these nights, participants will sleep only 3 hours prior to normal time of awakening. The WISP will deliver a small electrical current for one night and not for the other night, but participants will not know which. * For the other two nights, participants will follow a normal sleep schedule. The WISP will deliver a small electrical current for one night and not for the other night, but participants will not know which.

Key Dates

Start date
Oct 1, 2025
Status verified
May 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
16 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Sham Comparator: Sleep restriction, no TES
    Participants will have sleep restriction, sham TES
  • Experimental: Sleep restriction, TES
    Participants will have sleep restriction, will have active TES
  • Sham Comparator: Normal sleep, no TES
    Participants will follow normal sleep schedule, sham TES
  • Experimental: Normal sleep, TES
    Participants will follow normal sleep schedule, will have TES

Primary Outcome Measure

Multimodal MRI [ Time Frame: Immediately after the intervention with sleep condition and TES ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Washington School of MedicineSeattleWashington98125
Yeilim Cho, MD
[email protected]
(206) 277-7207

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By research site
University of Washington School of Medicine· Seattle, WA

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