Trends in Transfusion Strategies and Outcomes in Trauma

Part of paid clinical trials in Gainesville, Florida.

Sponsor
Mariah Arif
Study ID
NCT07603999
Status
Completed

Conditions

  • Blood Transfusion
  • Mortality
  • Transfusion
  • Trauma Coagulopathy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

This retrospective cohort study evaluated transfusion practices and outcomes in 137 severely injured trauma patients requiring massive transfusion at a Level I trauma center (2020-2025). This study analyzed balanced transfusion ratios, whole blood (WB) use, thromboelastography (TEG), and adjunctive hemostatic therapies to determine their impact on 30-day mortality and other clinical outcomes.

Key Dates

Start date
Jan 1, 2020
Status verified
May 2026
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
137 participants (actual)

Arms

  • Arm: Whole blood
    Patients who received whole blood
  • Arm: Not whole blood
    Patients who did not receive whole blood and instead only blood components

Primary Outcome Measure

30-day all cause mortality [ Time Frame: 30 days post-transfusion ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Florida Health Trauma One CenterGainesvilleFlorida32611-

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By research site
University of Florida Health Trauma One Center· Gainesville, FL

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