A Study of Ivonescimab in People With Non-Small Cell Lung Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07594522
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Photon or Proton standard stereotactic body radiotherapy (SBRT) — RADIATION
    Radiation therapy to start within 28 days after enrollment. Radiation therapy will be performed in accordance with institutional standard practice. Proton therapy and photon therapy are allowed as per standard of care in accordance with institutional practice.
  • Ivonescimab — DRUG
    Ivonescimab every 3 weeks on Day 1 of each Cycle as an intravenous (IV).

Study Details

The researchers are doing this study to find out whether ivonescimab after receiving standard stereotactic body radiotherapy (SBRT) is an effective treatment in people with Non-Small Cell Lung Cancer (NSCLC).

Key Dates

Start date
May 12, 2026
Status verified
May 2026
Primary completion
May 12, 2028
Completion
May 12, 2028

Study Design

Enrollment
36 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Ivonescimab Consolidation after Photon or Proton SBRT
    Patient will receive SBRT as part of usual care. About 4 to 6 weeks after SBRT, patient will receive ivonescimab during 21-day treatment Cycles.

Primary Outcome Measure

24-month event-free survival [ Time Frame: 24 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)CommackNew York11725
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Narek Shaverdian, MD
631-212-6323
Memorial Sloan Kettering Nassau (All Protocol Activities)UniondaleNew York11553
Narek Shaverdian, MD
631-212-6323

Find similar trials in Basking Ridge, NJ

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (All Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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