Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT07573228
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise training — OTHER
    15 weeks of HIIT exercise training

Study Details

The purpose of this study is: * To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program. * To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.

Key Dates

Start date
Feb 23, 2026
Status verified
May 2026
Primary completion
Jun 30, 2030
Completion
Jun 30, 2030

Study Design

Enrollment
60 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Type 1 diabetes - normal weight
    Type 1 diabetes normal weight
  • Active Comparator: Control - normal weight
    healthy control - normal weight
  • Active Comparator: Overweight control
    Overweight, otherwise healthy
  • Active Comparator: Type 1 diabetes - overweight
    Type 1 diabetes - overweight

Primary Outcome Measure

Microvascular blood volume in skeletal and cardiac muscle - changes from baseline [ Time Frame: Before and after 15 weeks of exercise training ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22908
Zhenqi Liu, MD
[email protected]
434-924-5247
Lee Hartline, MEd
[email protected]
434-924-5247
Zhenqi Liu, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Charlottesville, VA

By condition
Obesity / overweightType 1 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Virginia· Charlottesville, VA

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