Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Midwest Center for Metabolic and Cardiovascular Research
Study ID
NCT07566325
Status
Not Yet Recruiting

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Conditions

  • Hs-CRP
  • Obesity (BMI>30)
  • Overweight (BMI > 25)

Eligibility Criteria

Sex
ALL
Age
21 Years - 74 Years
Healthy Volunteers
Accepted

Interventions

  • Avocado — OTHER
    Active foods will provide the equivalent of one medium to large avocado/day in foods such as muffins and pudding, where avocado replaces refined carbohydrate, especially added sugars
  • Control — OTHER
    Control foods will have similar energy contents to active foods, but energy from avocado will be replaced with refined carbohydrate, especially added sugars.

Study Details

The objective of this trial is to assess the effects of replacing foods high in refined carbohydrates, particularly added sugars, with avocado (isocaloric substitution) on biomarkers of inflammation and insulin sensitivity in adults with elevated hs-CRP and central adiposity. Eligible participants will complete two 4-week interventions (1 avocado/d and control) separated by a 2-week washout phase. Participants will complete a total of 7 clinic visits including one screening visit (visit 1, -7 days), one baseline visit (visit 2, day 0), two visits during each 4-week diet condition (visit 3 \& 6 on day 21 and visits 4 \& 7 on day 28), and one visit at the conclusion of the washout phase/start of the second condition (visit 5, day 0).

Key Dates

Start date
May 11, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
38 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Avocado Group
    1 avocado/day provided by 3 servings study products per day (muffins and pudding)
  • Other: Control Group
    3 study products per day will be provided with energy from avocado will be replaced with refined carbohydrate, especially added sugars

Primary Outcome Measure

Composite measure of inflammatory biomarkers [ Time Frame: Change from baseline (day 0) to end of each condition (day 28) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Illinois Institute of TechnologyChicagoIllinois60616
Chelsea Preiss
[email protected]
312-567-5300
University of Nevada, Las VegasLas VegasNevada89154
Neda Akhavan
[email protected]
702-895-3011

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By research site
Illinois Institute of Technology· Chicago, ILUniversity of Nevada, Las Vegas· Las Vegas, NV

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