Effect of Ketone Esters on Liver Fat Content and Metabolic Function

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT07097506
Phase
PHASE2
Status
Recruiting
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Conditions

  • MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
  • Obesity
  • Overweight (BMI > 25)

Eligibility Criteria

Sex
ALL
Age
18 Years - 25 Years
Healthy Volunteers
Accepted

Interventions

  • bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester) — DRUG
    25 g C8 ketone di-ester taken daily for approximately 6-weeks
  • Placebo — OTHER
    25 g Placebo taken daily for approximately 6-weeks

Study Details

The goal of this clinical trial is to determine whether ingestion of a ketone ester drink helps improve liver health and blood glucose control. Ketones are a type of energy source made by the body during times of weight loss, low carbohydrate intake and starvation. People enrolled in this study will be randomly assigned (by chance, like the flip of a coin) to one of two groups: Group 1: Ketone ester drink consumed daily for 6 weeks. Group 2: Placebo drink consumed daily for 6 weeks.

Key Dates

Start date
Sep 26, 2025
Status verified
Nov 2025
Primary completion
Jul 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
    25 g Placebo per day for approximately 6-weeks
  • Experimental: C8 ketone di-ester
    25 g C8 ketone di-ester per day for approximately 6-weeks

Primary Outcome Measure

Change in Intrahepatic triglyceride content [ Time Frame: Before and at the end of treatment at 6-weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110
Nikki Plassmeyer, RDN, LD
[email protected]
314-362-0590
Central contact information
[email protected]
314-273-1879

Find similar trials in St Louis, MO

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Washington University School of Medicine· St Louis, MO

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