Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle Interventions to Lose Weight and Reduce EDC Exposure in Individuals With Overweight/Obesity

Part of paid clinical trials in Berkeley, California.

Sponsor
Million Marker Wellness, Inc.
Study ID
NCT07560579
Status
Active Not Recruiting

Conditions

  • Environmental Exposure
  • Obesity &Amp;Amp;Amp; Overweight
  • Overweight (BMI > 25)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Educational curriculum — BEHAVIORAL
    A self-directed online interactive curriculum of EDC material, with access to live coaches and an online forum.
  • Weight loss Application — BEHAVIORAL
    A paid, self-directed weight loss application.
  • Urinary EDC metabolite testing — DIAGNOSTIC_TEST
    Mail-in urine samples tested for metabolites of bisphenols, phthalates, parabens, and oxybenzone.
  • Siphox clinic biomarker test — DIAGNOSTIC_TEST
    Mail-in blood samples tested for clinical biomarkers.
  • Weight loss reporting — DIAGNOSTIC_TEST
    Self-reported weight loss.

Study Details

The goal of this study is to examine the relationship in individuals with overweight/obesity and endocrine disrupting chemical (EDC) exposure through a two-armed, randomized clinical trial. The main questions this study aims to answer are: 1. If MM's 12-week EDC intervention program (EDC testing and report-back, EDC reduction curriculum) can reduce weight? 2. If a 12-week validated digital weight loss program can reduce EDC exposures? 3. What is the effectiveness of the two interventions at reducing weight and urinary EDC metabolites? Participants will be assigned to one of these two arms. Participants will collect their urine and blood samples pre- and post-intervention, and will take a comprehensive exposure survey before sending back their samples. This exposure survey will ask about participant's weight loss literacy, environmental health literacy, product use, diet, and lifestyle behaviors.

Key Dates

Start date
Aug 18, 2025
Status verified
May 2026
Primary completion
Aug 31, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
226 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Weight Loss Group
    Individuals will be recruited to this following the same eligibility and recruitment parameters of the EDC intervention group. The weight loss intervention group will use a weight loss application for 12 weeks. Participants will receive a MM test kit and Siphox kit at baseline, before starting the weight loss intervention, and after 12 weeks of engaging with the weight loss program. They will not undergo any EDC lifestyle auditing. Additionally, in order to reduce bias, these participants will not receive the results of their EDC testing and recommendations for reducing exposure until after the study has been completed, at which point they will receive both their baseline and post-intervention EDC exposure results.
  • Experimental: EDC Reduction Intervention Group
    Participants will be required to attend 2 food/product/lifestyle audit sessions, complete at least 6 out 12 of the modules in the intervention course and complete pre-post intervention surveys. Participants will be guided through this journey from our online instructions, online video tutorials, extensive educational materials, and email communication.

Primary Outcome Measure

Changes in weight after intervention. [ Time Frame: Pre and post intervention (4 months between measurements) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Million MarkerBerkeleyCalifornia94704-

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