Developmental Impacts of Microplastics Exposure in Early Life

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins Bloomberg School of Public Health
Study ID
NCT06107933
Status
Recruiting
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Conditions

  • Breast Feeding
  • Environmental Exposure
  • Infant Development

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Observational only — OTHER
    Exposure to micro and nano plastics

Study Details

The goal of this observational study is to characterize and evaluate micro- and nano-plastic (MNP) exposures among mothers and infants in mother-infant dyads 1 or 3 months postpartum living in Baltimore, Maryland. The main questions it aims to answer are: * What MNPs are present in breastmilk and maternal blood samples and in their infants stool sample? * Are there associations between amount of maternal MNPs in breast milk and mass of MNP particles in infant stool? * Which environmental and lifestyle factors are most predictive of maternal MNP burden? * Is infant exposure to MNPs associated with birth weight and postnatal growth trajectories? Participants will: * Complete several questionnaires assessing medical histories, lifestyle factors, environmental exposures, eating behaviors, etc. * Provide biological specimens including: maternal blood, stool, and breastmilk; infant stool * Clinical visit to have anthropometric measures documented including maternal height and weight, infant weight, length, and skin-fold thickness

Key Dates

Start date
Oct 1, 2023
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Jan 1, 2027

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: City Mother-Infant Pairs
    Mother-infant pairs living in a Baltimore City, Maryland zip code exposed to micro and nano plastics.
  • Arm: County Mother-Infant Pairs
    Mother-infant pairs living in a Baltimore County, Maryland zip code exposed to micro and nano plastics.

Primary Outcome Measure

Microplastic composition in maternal breastmilk [ Time Frame: 1 or 3 months +/- 2 weeks postpartum ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
East Baltimore Pediatric Inpatient and Outpatient Clinical Research UnitBaltimoreMaryland21287
Rachel Salamone, RN
[email protected]
410-614-6365

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By research site
East Baltimore Pediatric Inpatient and Outpatient Clinical Research Unit· Baltimore, MD

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