Effect of PEEP on Cardiac Function

Conditions

• Cardiac Surgery Subjects

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• EIT Guided PEEP Trial — PROCEDURE
  Electrical impedance tomography (EIT) will be used to guide identification of "optimal PEEP" based on lung mechanics. After induction of anesthesia and initiation of controlled mechanical ventilation, EIT data will be collected during a brief standardized PEEP titration maneuver to assess lung recruitment and overdistension.

Study Details

The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.

Key Dates

Start date

Jul 15, 2026

Status verified

Apr 2026

Primary completion

Jul 30, 2028

Completion

Oct 30, 2028

Study Design

Enrollment

28 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Optimized PEEP Group
  These are patients undergoing cardiac surgery who will undergo an incremental/decremental PEEP trial using Electrical Impedance Tomography (EIT).

Primary Outcome Measure

Right ventricle-pulmonary artery coupling (Ees/Ea) [ Time Frame: During the standardized PEEP titration sequence after induction of anesthesia and before surgical intervention (approximately 20-25 minutes) ]

Central Contacts

• Arian Karimitar, PhD
  6176328056
  [email protected]
• Vahid Kiarad, MD, MPH
  [email protected]

Locations (1)

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