A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)

Part of paid clinical trials in Anniston, Alabama.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07528508
Phase
PHASE1
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • MK-8527 — DRUG
    Tablet for oral administration.
  • Methadone — DRUG
    Formulated per local guidelines, administered orally.

Study Details

The goal of this study is to learn about the effect of a study medicine called MK-8527 when taken with methadone. The study will also measure what happens to the methadone in a healthy person's body over time after MK-8527 is taken.

Key Dates

Start date
May 22, 2026
Status verified
May 2026
Primary completion
Aug 10, 2026
Completion
Aug 10, 2026

Study Design

Enrollment
14 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Methadone + MK-8527
    Participants will receive methadone and MK-8527.

Primary Outcome Measure

Dose-Normalized Area Under the Plasma Concentration Time Curve From 0-24 Hours Postdose (AUC0-24) of R-Methadone [ Time Frame: Up to 24 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Pinnacle Research Group ( Site 0002)AnnistonAlabama36207
Study Coordinator
256-236-0055

Find similar trials in Anniston, AL

By research site
Pinnacle Research Group· Anniston, AL

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