The Meta-SHIFT Study: How Metabolic Shift Shapes Human Immunometabolism - a Fasting Trial

Part of paid clinical trials in Ithaca, New York.

Sponsor
Cornell University
Study ID
NCT07527208
Status
Recruiting
Apply to this trial

Conditions

  • Fasting

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Fasting — OTHER
    After consumption of a standardized breakfast (energy content adjusted to individual BMR), participants will undergo a 26-hour fast (water only), followed by consumption of a second standardized breakfast.

Study Details

During fasting, the body shifts from using carbohydrates to relying more on fat as its main source of energy. This process is known as the 'metabolic shift'. Fat tissue helps supply this energy by breaking down stored fat into fatty acids, which are released into the bloodstream and transported to organs throughout the body. In addition to fatty acids, many other substances in the blood (such as metabolites) change during fasting to help maintain normal body function. Immune cells also circulate in the blood and play an important role in protecting the body against infections and diseases such as cancer. However, it is not yet well understood how the metabolic shift during fasting affects immune cell function. The purpose of this study is to investigate how 24 hours of fasting influences immune cell metabolism and function.

Key Dates

Start date
Jun 1, 2026
Status verified
Apr 2026
Primary completion
Aug 28, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
28 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Fasting
    26-hour fasting

Primary Outcome Measure

Change in PBMC energy metabolism. [ Time Frame: Baseline, 24 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Human Metabolic Research Unit, Division of Nutritional Sciences. Cornell UniversityIthacaNew York14853
Sander Kersten, Ph.D.
[email protected]
607-255-8001

Find similar trials in Ithaca, NY

By research site
Human Metabolic Research Unit, Division of Nutritional Sciences. Cornell University· Ithaca, NY

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