Immunomodulatory Effects of Fasting in Healthy Adults

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT05104502
Status
Recruiting
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Conditions

  • Fasting

Eligibility Criteria

Sex
ALL
Age
20 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Dietary Fasting — BEHAVIORAL
    The study will consist of two days of eating a "controlled habitual diet" and one 36-hour period of water-only fasting with glucose monitoring as a measure of compliance. Water intake will be limited to 2 liters/day to prevent electrolyte abnormalities. Subjects will undergo 4 separate blood-draws consisting of an overnight fasted sample (Baseline), a 2-hour postprandial sample (Fed), a 36-hour fasted sample (Fasted), and final 2-hour postprandial sample after the fasting period (Refed).

Study Details

This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.

Key Dates

Start date
Mar 25, 2022
Status verified
Nov 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
4 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Fasting
    Dietary fasting.

Primary Outcome Measure

Changes in peripheral blood mononuclear cells [ Time Frame: 7 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UC DavisSacramentoCalifornia95816
Antonio Ji-Xu

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UC Davis· Sacramento, CA

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