Lily's Grace Temporal Interference

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT07520955
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • TES-TI — DEVICE
    Real stimulation will take place on visits 2 - 5 or visits 6 - 10.
  • Sham Stimulation — OTHER
    Sham stimulation will take place on visits 2 - 5 or visits 6 - 10.
  • Structural and Functional MRI — OTHER
    After baseline night visit 1 and before intervention visits 2 - 10. MRI is used to help determine electrode placement.

Study Details

This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional health in patients with epilepsy. Up to 24 participants (8 control participants for technical optimization prior to recruitment and 16 patients with epilepsy) will be enrolled and can expect to be on study for up to 24 months.

Key Dates

Start date
Jun 30, 2026
Status verified
Apr 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
24 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Sham Stimulation then Real Stimulation
    Each participant will undergo structural and functional MRI then eight nights of intervention with possible sham or non-sham stimulation conditions.
  • Experimental: Real Stimulation then Sham Stimulation
    Each participant will undergo structural and functional MRI then eight nights of intervention with possible sham or non-sham stimulation conditions.

Primary Outcome Measure

NREM Sleep Slow-Wave Activity Measured by High-Density EEG (delta power) [ Time Frame: measured during 8 overnight visits, data collected up to 24 months on study ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UW School of Medicine and Public HealthMadisonWisconsin53792-

Find similar trials in Madison, WI

By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
UW School of Medicine and Public Health· Madison, WI

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