Outcomes of Different Bone Graft Combinations for Maxillary Sinus Augmentation Procedure

Conditions

• Bone Grafting
• Sinus Lifting

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Not accepted

Interventions

• Bone grafting on both sides — DEVICE
  The surgical protocol is part of standard of care and will not be changed due to the study except the choice of the bone graft. Routinely (as the standard protocol), allograft (Straumann Allograft mineralized cortical granules \[0.25-1mm\]) is mixed with xenograft (bovine bone; Bio-Oss® small particles \[0.25-1mm\]) bone graft and placed into sinus. In this study, one randomly chosen sinus will receive this mixture (50:50 by volume) as the control. The other sinus on the same patient will receive a 50:50 (by volume) mixture of the same allograft with synthetic carbonate apatite (Cytrans® granules S size \[0.3-0.6 mm\]).

Study Details

This study investigates the outcomes of a surgical procedure that is performed to increase bone support at a future implant site on the upper back jaw area. This procedure requires placing bone graft material and/or substitutes into the maxillary sinus. The average healing time for the graft is about 6 months. Then, the site will be ready for dental implant. The study will compare healing outcomes of two types of bone graft mixtures used on the same patient (right and left upper jaw regions). The outcomes will be evaluated through clinical examination but also by studying the quality of the tissue through tissue biopsies obtained from grafted sites.

Key Dates

Start date

Jun 30, 2026

Status verified

Apr 2026

Primary completion

Jun 30, 2027

Completion

Jun 30, 2027

Study Design

Enrollment

10 participants (estimated)

Arms

• Arm: Bone graft patients
  Patients who are missing their upper back teeth and interested in having implant supported dental restorations, and who require direct sinus augmentation procedure on both right and left maxillary sinus prior to implant placement.

Primary Outcome Measure

Change in ridge dimensions [ Time Frame: Prior to procedure; 10 days post-procedure; 1 month post-procedure; 6 months post-procedure ]

Central Contacts

• Binnaz Leblebicioglu, DDS, MS, PhD
  614-292-0371
  [email protected]

Locations (1)

Find similar trials in Columbus, OH

Related Studies

• Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix
  Not Yet Recruiting · University of Alabama at Birmingham · Birmingham, Alabama