Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma

Part of paid clinical trials in San Francisco, California.

Sponsor
University of California, San Francisco
Study ID
NCT07506239
Status
Recruiting
Apply to this trial

Conditions

  • Low Grade Glioma of Brain
  • Low-grade Glioma
  • Pediatric Cancer
  • Recurrent Low Grade Glioma

Eligibility Criteria

Sex
ALL
Age
2 Years - 25 Years
Healthy Volunteers
Not accepted

Interventions

  • Laser Interstitial Thermal Therapy (LITT) — DEVICE
    Perform ablation using LITT
  • Magnetic resonance imaging (MRI) — PROCEDURE
    Undergo single imaging procedure
  • Questionnaires — OTHER
    Participants will complete questionnaires

Study Details

This study aims to evaluate the efficacy of Laser Interstitial Thermal Therapy (LITT) in treating recurrent or progressive, low-grade gliomas (LGG) in pediatric, adolescent and young adult patients.

Key Dates

Start date
Mar 25, 2026
Status verified
Mar 2026
Primary completion
Jan 1, 2030
Completion
Jan 1, 2031

Study Design

Enrollment
40 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Experiment: Laser Interstitial Thermal Therapy (LITT)
    Participants will receive LITT and imaging and complete a set of questionnaires pre- and again at 3 months, 1 year, and 2 years post-treatment post- procedure. Participants will be closely monitored for any immediate complications and recovery progress, with a safety follow-up visit scheduled at 14 and 28 days after the LITT procedure. Imaging data from the medical record will also be obtained for up to 24 months and participants will also be co-enrolled in the PNOC COMP protocol, with follow-up procedures documented under this protocol until death or withdrawal from the study.

Primary Outcome Measure

Proportion of participants with Progression-free Survival (PFS) [ Time Frame: up to 15 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San FranciscoSan FranciscoCalifornia94143
PNOC Operations Office
[email protected]
415-502-1600
[email protected]
877-827-3222
Sabine Mueller, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in San Francisco, CA

By research site
University of California, San Francisco· San Francisco, CA

Related Studies