Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

Part of paid clinical trials in San Diego, California.

Sponsor
Hari Narayan
Study ID
NCT04262830
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
13 Years - 39 Years
Healthy Volunteers
Not accepted

Interventions

  • Cardiac magnetic resonance imaging (MRI) — DIAGNOSTIC_TEST
    Cardiac magnetic resonance imaging will be performed to evaluate cardiac remodeling, function, and tissue characteristics
  • Accelerometer physical activity monitoring — OTHER
    Measurement of physical activity using hip-worn accelerometer.

Study Details

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Key Dates

Start date
Sep 30, 2019
Status verified
Jan 2025
Primary completion
Sep 30, 2028
Completion
Sep 30, 2030

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: All Study Participants
    This is an observational study where all study participants are within a single group. Participants will have testing performed at baseline and again at follow-up \>= 3 years after the initial assessment.

Primary Outcome Measure

Left ventricular ejection fraction (LVEF) [ Time Frame: 3 - 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rady Children's HospitalSan DiegoCalifornia92123
Hari Narayan, MD
[email protected]
858-966-5855
Maria Teresa Acuero, MAS
[email protected]
8585761700
Hari Narayan, MD (PRINCIPAL_INVESTIGATOR)
Dennis Kuo, MD (SUB_INVESTIGATOR)
Mark Abcede, MBA (SUB_INVESTIGATOR)
Maria Teresa Acuero, MAS (SUB_INVESTIGATOR)
Cesar Vasquez, BS (SUB_INVESTIGATOR)

Find similar trials in San Diego, CA

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Rady Children's Hospital· San Diego, CA

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