Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health

Part of paid clinical trials in Saint Charles, Missouri.

Sponsor
Lindenwood University
Study ID
NCT07502924
Status
Recruiting
Apply to this trial

Conditions

  • Body Composition
  • Muscle Health
  • Muscle Strength

Eligibility Criteria

Sex
ALL
Age
30 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • Dietary Supplement - Placebo — DIETARY_SUPPLEMENT
    Participants will ingest a placebo consisting of olive oil daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.
  • Geranylgeraniol (150 mg) — DIETARY_SUPPLEMENT
    Participants will ingest 150 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.
  • Geranylgeraniol (300 mg) — DIETARY_SUPPLEMENT
    Participants will ingest 300 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.

Study Details

This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial lasting 8 weeks. Participants will be assigned to receive either placebo, 150 mg GG, or 300 mg GG daily. Outcome measures will be assessed at baseline, week 4, and week 8 and include maximal strength (1RM bench press and leg press), fat-free mass, muscular endurance, aerobic capacity (VO2peak), and circulating biomarkers related to metabolism and health.

Key Dates

Start date
Mar 3, 2025
Status verified
Mar 2026
Primary completion
Aug 1, 2026
Completion
Aug 1, 2026

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo Comparator
    Participants will ingest a placebo consisting of olive oil daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.
  • Active Comparator: 150 mg Geranylgeraniol
    Participants will ingest 150 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.
  • Active Comparator: 300 mg Geranylgeraniol
    Participants will ingest 300 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.

Primary Outcome Measure

Leg Press One-Repetition Maximum (1RM) [ Time Frame: Change from baseline (Week 0) to Week 8 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Lindenwood University Exercise and Performance Nutrition LaboratorySaint CharlesMissouri63301
Anthony M Hagele, MS
[email protected]
636-949-4785
Joesi M Morey, MS
[email protected]

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Lindenwood University Exercise and Performance Nutrition Laboratory· Saint Charles, MO

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