DXA Study of Precision and Reliability

Part of paid clinical trials in University Park, Pennsylvania.

Sponsor
Penn State University
Study ID
NCT03621306
Status
Recruiting
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Conditions

  • Body Composition
  • Bone and Bones

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • DXA and pQCT precision testing — DEVICE
    The participants are only being observed; there is no intervention other than DXA and pQCT testing for the purposes of looking at instrument/technician precision..

Study Details

The purpose of the study is to assess precision of the GE Lunar iDXA, Hologic Horizon W DXA scanner, and the Stratec peripheral quantitative computed tomography (pQCT) scanner. Aim 1: To assess standard deviation (SD) and coefficient of variation (CV) of testing bone mineral, bone geometry, and soft tissues in inanimate objects and adults. Tests on adults will be structured to assess: 1. Within- and between-day variability of testing 2. Within- and between-technician variability of testing 3. Variability due to positioning and post-scan processing 4. Variability due to different DXA scanning equipment Aim 2: To assess the least significant change (LSC) for testing bone mineral and soft tissues in adults. Aim 3: To assess strengths and limitations of DXA and pQCT testing, including sensitivity to movement, rate of re-rescanning, etc. which are crucial components for demonstrating feasibility in grant applications. Aim 4: To construct a database of DXA and pQCT test results and quality control procedures, showing our laboratory's quality control level.

Key Dates

Start date
Jun 16, 2008
Status verified
May 2025
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
400 participants (estimated)

Arms

  • Arm: Men and women aged 18+
    Men and women over the age of 18

Primary Outcome Measure

Precision of iDXA BMD [ Time Frame: One month ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Women's Health and Exercise Laboratories, The Pennsylvania State UniversityUniversity ParkPennsylvania16802
Mary Jane De Souza, PhD
[email protected]
814-863-0045
Nancy I Williams, Sc.D. (SUB_INVESTIGATOR)
Mary Jane De Souza, Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
Women's Health and Exercise Laboratories, The Pennsylvania State University· University Park, PA

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