Effect of the Combination of Nitrate and Caffeine on Critical Power In Trained Male Cyclists

Part of paid clinical trials in Saint Charles, Missouri.

Sponsor
Lindenwood University
Study ID
NCT07501806
Status
Completed

Conditions

  • Cycling Performance
  • Exercise Performance
  • Exercise Performance of Fit Athletes

Eligibility Criteria

Sex
MALE
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Dietary Nitrate — DIETARY_SUPPLEMENT
    Participants consume concentrated nitrate-rich beetroot juice providing approximately 8.2 mmol of nitrate 3 hours prior to exercise.
  • Caffeine — DIETARY_SUPPLEMENT
    Participants consume caffeine at a dose of 5 mg/kg body mass in capsule form 60 minutes prior to exercise.
  • Placebo — OTHER
    Participants consume a nitrate-depleted beetroot juice placebo approximately 2-3 hours prior to exercise and a placebo capsule (maltodextrin) approximately 60 minutes prior to exercise.

Study Details

This study is investigating the independent and combined effects of acute dietary nitrate and caffeine supplementation on performance during a 3-minute all-out cycling test in trained male cyclists. In a randomized, double-blind, placebo-controlled, crossover design, participants will complete four experimental conditions: nitrate, caffeine, nitrate plus caffeine, and placebo. Primary outcomes include end power (EP) and work done above end power (WEP), surrogate measures of critical power and W'. The study aims to determine whether combined supplementation provides additive benefits for severe-intensity exercise performance.

Key Dates

Start date
Nov 17, 2020
Status verified
Mar 2026
Primary completion
Nov 11, 2021
Completion
Nov 11, 2021

Study Design

Enrollment
15 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nitrate + Caffeine (BR + CAF)
    Participants consume nitrate-rich beetroot juice 3 hours prior to exercise and caffeine 60 minutes prior to exercise.
  • Experimental: Nitrate Only (BR)
    Participants consume nitrate-rich beetroot juice 3 hours prior to exercise and placebo capsule 60 minutes prior to exercise.
  • Experimental: Caffeine Only (CAF)
    Participants consume nitrate-depleted placebo 3 hours prior to exercise and caffeine 60 minutes prior to exercise.
  • Placebo Comparator: Placebo (PLA)
    Participants consume nitrate-depleted placebo 3 hours prior to exercise and placebo 60 minutes prior to exercise

Primary Outcome Measure

End Power [ Time Frame: Assessed during a single 3-minute all-out cycling test, approximately 3 hours following supplementation ]

Locations (1)

FacilityCityStateZIPSite coordinators
Exercise and Performance Nutrition LaboratorySaint CharlesMissouri63301-

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