Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)

Part of paid clinical trials in Cambridge, Massachusetts.

Sponsor
Massachusetts Institute of Technology
Study ID
NCT07496918
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Accepted

Interventions

  • GENUS — DEVICE
    The device is a light and sound device that delivers light stimulation using light-emitting diodes (LED) and sound stimulation through a speaker, with a centrally-mounted tablet or phone that plays videos for entertainment. The device will be positioned on an easel such that the tablet is eye level with the participant while they are sitting 5 feet away or held in their hands. The active device delivers light and sound at 40Hz rate.
  • Tactile GENUS — DEVICE
    The device is a wrist worn or hand held device that vibrates or otherwise generates tactile stimulation at specific frequencies.

Study Details

Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in dementia. Development of a non-invasive medical device that is effective in slowing cognitive impairment is not only revolutionary but also possibly cost- effective. In this study, participants will come to MIT for a 1-day visit and the investigators will evaluate the effects of GENUS in cognitively normal, healthy adults. Investigators will use Electroencephalogram (EEG), Magnetoencephalography (MEG), magnetic resonance imaging (MRI), neuropsychological testing, and blood sampling in subsets of participants to evaluate for biological effects and safety of GENUS stimulation.

Key Dates

Start date
Feb 20, 2018
Status verified
Mar 2026
Primary completion
Jan 30, 2027
Completion
Jan 30, 2027

Study Design

Enrollment
150 participants (estimated)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Cognitively normal adults
    Cognitively normal, healthy adults aged 18 - 100

Primary Outcome Measure

Effects of GENUS on brain oscillations [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
MITCambridgeMassachusetts02139
Ana Trisini Lipsanopoulos, BS
[email protected]
617-258-7723
Ana Trisini Lipsanopoulos, BS (SUB_INVESTIGATOR)

Find similar trials in Cambridge, MA

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
MIT· Cambridge, MA

Related Studies