Burn Pit Exposure in Veterans: A Cancer Screening Pilot Study at the Inova Saville Cancer Screening & Prevention Center

Part of paid clinical trials in Fairfax, Virginia.

Sponsor
Inova Health Care Services
Study ID
NCT07485322
Status
Not Yet Recruiting

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Conditions

  • Cancer

Eligibility Criteria

Sex
ALL
Age
35 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Avantect Multi-Cancer Detection Test — DEVICE
    Multi-cancer blood test to detect cancer DNA. Manufactured by ClearNote Health.
  • Nasal Swab — DIAGNOSTIC_TEST
    Two nasal brush swabs will be collected during the baseline screening period. The brushing of the inside of the nose is performed using a soft brush, with local anesthetic if necessary.

Study Details

The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening regimen in veterans exposed to burn pits. The study results may describe the clinical and psychosocial impact such screening has on this potential population. The study hopes to share the premalignant and malignant findings identified and follow-up healthcare utilization associated with high-intensity cancer screening during the approximately 3-year study period (three annual screening assessments and an additional year of follow-up to determine participants' cancer status). The study will also explore the performance of new tools (nasal brush, multi-cancer detection blood test, and radiomic analysis) in detecting the development of cancer during the study period.

Key Dates

Start date
May 2, 2026
Status verified
Apr 2026
Primary completion
Apr 28, 2029
Completion
Jul 31, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Veterans exposed to burn pits
    Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for \>1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).

Primary Outcome Measure

STAI Questionnaire [ Time Frame: 3.5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Inova Schar Cancer InstituteFairfaxVirginia22031
Saville Research
[email protected]
571-472-3500
Rebecca Kaltman, MD (PRINCIPAL_INVESTIGATOR)
Jennifer Lund, DO (SUB_INVESTIGATOR)
Bryan Bassig, PhD (SUB_INVESTIGATOR)

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By research site
Inova Schar Cancer Institute· Fairfax, VA

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