A Study Of T1/Tref Intubating Conditions

Part of paid clinical trials in Jacksonville, Florida.

Sponsor
Mayo Clinic
Study ID
NCT07483164
Status
Enrolling By Invitation

Conditions

  • Intubation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Twitch amplitude <0.1 — DEVICE
    (T1/Tref) \<0.1
  • Twitch amplitude <0.3 — OTHER
    (T1/Tref) \<0.3
  • Twitch amplitude <0.5 — OTHER
    (T1/Tref) \<0.5

Study Details

The purpose of this study is to determine the maximum ratio of the twitch amplitude (T1) to the reference twitch (Tref) amplitude (T1/Tref) that provides excellent intubating conditions.

Key Dates

Start date
May 31, 2026
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
108 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: T1/Tref <0.1
    Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude (T1/Tref) \<0.1 (deeper level of block)
  • Experimental: T1/Tref <0.3
    Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref \<0.3 (intermediate depth of block)
  • Experimental: T1/Tref <0.5
    Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref \<0.5 (shallower level of block)

Primary Outcome Measure

Maximum T1/Tref ratio associated with excellent intubating conditions [ Time Frame: Baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in FloridaJacksonvilleFlorida32224-

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By research site
Mayo Clinic in Florida· Jacksonville, FL

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