EMS-Initiated Buprenorphine

Part of paid clinical trials in Oakland, California.

Sponsor
Yale University
Study ID
NCT07475728
Status
Not Yet Recruiting

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Conditions

  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

This is a multisite EMS study that will first conduct a sequence of pragmatic, prehospital field studies to provide preliminary feasibility, acceptability, and safety data for refinement and enhancement of a subsequent single-arm prospective trial that will provide preliminary effectiveness data, from which to build a larger randomized control trail (RCT) trial.

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Mar 31, 2029
Completion
May 31, 2029

Study Design

Enrollment
495 participants (estimated)

Arms

  • Arm: Participants
    Individuals with opioid use disorder (OUD) who encounter Emergency Medical Services (EMS) in the prehospital setting under one of two circumstances: (1) They have experienced an overdose requiring naloxone reversal or (2) They are in acute opioid abstinence withdrawal and are offered an EMS-initiated BUP clinical protocol.

Primary Outcome Measure

Primary Outcome Measure for Pragmatic Field Study [ Time Frame: Baseline ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Alameda Health SystemOaklandCalifornia94602
Andrew Herring, MD
[email protected]
(510) 437-4800
Hennepin HealthcareMinneapolisMinnesota55415
Nicholas Simpson, MD
[email protected]
(612) 873-3000
Cooper University HospitalCamdenNew Jersey08103
Gerard Carroll, MD
[email protected]
Jessica Heil
[email protected]

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