Serum Inflammatory Protein Concentration During Dental Treatment

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT07468929
Status
Not Yet Recruiting

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Conditions

  • Periodontal Disease
  • Periodontal Surgery

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Blood samples for inflammatory markers — OTHER
    Blood samples will be obtained before the start of the procedure, the midpoint of the procedure, and the end of the procedure.
  • periodontal surgery — PROCEDURE
    Periodontal/peri-implant surgical interventions, with or without IV sedation, as based on treatment needs
  • Periodontal maintenance — PROCEDURE
    Regular cleaning to maintain health after surgical treatment for periodontal disease
  • Non-surgical deep cleaning — PROCEDURE
    Debridement under local anesthesia, as based on treatment needs

Study Details

The goal of this observational study is to study the molecular markers of stress in blood samples from people who are having periodontal surgery. The main question it aims to answer are: * How do the levels of inflammatory molecules in the blood change during a periodontal surgery? * How are the levels of inflammatory molecules in a person having surgery different from the levels in a person having a nonsurgical procedure? * Participants will be people who are having a periodontal surgery or a nonsurgical periodontal treatment as part of their dental care. Participants will be asked to let the investigator take blood samples from them before, during, and after the procedure is being done. The blood will later be analyzed for substances in the blood that are associated with inflammation.

Key Dates

Start date
May 31, 2026
Status verified
Apr 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Control group 1
    Recruited from patients who have already received active treatment to control their disease and are now in periodontal maintenance program (regular cleaning).
  • Arm: Control group 2
    Recruited from patients who are receiving non-surgical deep cleaning (debridement under local anesthesia)
  • Arm: Surgical group
    Recruited from patients who are treatment planned for periodontal/peri-implant surgical interventions.

Primary Outcome Measure

Serum CRP concentration (pg/ml) [ Time Frame: Immediately prior to procedure; approximately midway through the procedure; immediately after procedure ends; ]

Locations (1)

FacilityCityStateZIPSite coordinators
The Ohio State University Graduate Periodontics ClinicColumbusOhio43210-

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The Ohio State University Graduate Periodontics Clinic· Columbus, OH

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