A Study of Elranatamab and Cyclophosphamide in People With Multiple Myeloma

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07454382
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Elranatamab-bcmm — BIOLOGICAL
    Elranatamab-bcmm is a recombinant, humanized, bispecific IgG2 kappa antibody
  • Cyclophosphamide — DRUG
    Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards

Study Details

The purpose of this study is to find out whether the combination of elranatamab and cyclophosphamide is an effective treatment for people with relapsed/refractory multiple myeloma (MM) who have risk factors that may affect how well their disease would respond to elranatamab alone.

Key Dates

Start date
Feb 27, 2026
Status verified
Mar 2026
Primary completion
Aug 27, 2029
Completion
Aug 27, 2029

Study Design

Enrollment
26 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Multiple Myeloma
    Participants must have pathologically confirmed diagnosis of multiple myeloma (MM) as defined according to 2014 IMWG criteria

Primary Outcome Measure

Complete response rate [ Time Frame: 6 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (All Protocol Activities)CommackNew York11725
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Alexander Lesokhin, MD
646-608-3717
Memorial Sloan Kettering Nassau (Limited Protocol Activities)UniondaleNew York11553
Alexander Lesokhin, MD
646-608-3717

Find similar trials in Basking Ridge, NJ

By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Cancer Center @ Suffolk-Commack (All Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

Related Studies