Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT07453537
Status
Recruiting
Apply to this trial

Conditions

  • Cognitive Symptoms
  • Mental Stress
  • Motor Activity
  • Multitasking Behavior and Multitasking Ability
  • Physiological Stress
  • Stress Response

Eligibility Criteria

Sex
ALL
Age
30 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Cranberry juice — OTHER
    Participants will consume the cranberry juice beverage by mouth each day for 70 days following a run-in period.
  • Placebo juice — OTHER
    Participants will consume the placebo cranberry juice beverage by mouth each day for 70 days following a run-in period.

Study Details

This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2/Hypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3/Hypothesis 3).

Key Dates

Start date
Apr 1, 2026
Status verified
Jan 2026
Primary completion
May 1, 2028
Completion
Aug 1, 2029

Study Design

Enrollment
84 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Cranberry juice
    Cranberry juice will be provided by Ocean Spray Company.
  • Placebo Comparator: Placebo cranberry juice
    Placebo juice will be provided from Ocean Spray Company to match the appearance, taste, and calories of the cranberry beverage; it contains no active cranberry components.

Primary Outcome Measure

Cognitive task performance (serial subtraction accuracy) [ Time Frame: Baseline (Visit 2) and Final (Visit 3, Day 70). Through study completion (average of 2 years). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32608
Maya Waintraub, M.S.
[email protected]
847-246-2255
lewei Gu, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Gainesville, FL

By research site
University of Florida· Gainesville, FL

Related Studies