Assessing the Efficacy and Safety of Photobiomodulation for the Treatment of Pruritus

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT07450716
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Pruritus

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Light-emitting diode (LED) Photobiomodulation (PBM) device — DEVICE
    Near-infrared light treatment will be administered to an area on the body experiencing itch.
  • Placebo — OTHER
    Matching placebo delivered by placing the device above the skin on an area contralateral to the treatment area without activating it.

Study Details

This study is designed to evaluate the safety and effectiveness of a low-level near-infrared LED light device for relieving itch. The device is non-invasive, does not break the skin, and does not produce heat. Near-infrared light has been used in other medical settings and is known to interact with skin and nerve pathways. In this study, researchers are examining whether this light can be safely applied to the skin and whether it may help reduce itch by affecting signals involved in itch sensation.

Key Dates

Start date
Apr 30, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Matching placebo
    Matching placebo delivered by placing the device above the skin without activating it.
  • Experimental: Low-Level Near-Infrared LED Light Treatment
    Near-infrared light treatment will be administered to an area on the body experiencing itch.

Primary Outcome Measure

Peak Pruritus Numerical Rating Scale (PP-NRS) [ Time Frame: Once daily for 7 days prior to the first treatment visit; each treatment visit; once daily for 7 days after the final treatment visit--Days -7~6, Days 13~20. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wellman Center for Photomedicine, Massachusetts General HospitalBostonMassachusetts02115
Clinical Research Coordinator
[email protected]
617-724-2168
Margaret Chou, MD (SUB_INVESTIGATOR)
Bridget Myers, MD (SUB_INVESTIGATOR)
Richard R. Anderson, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By research site
Wellman Center for Photomedicine, Massachusetts General Hospital· Boston, MA

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