Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT07443891
Status
Recruiting
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Conditions

  • Laryngeal Dystonia

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Vibrotactile Stimulation (VTS) — DEVICE
    Applied to the laryngeal area using a non-invasive vibrating device.

Study Details

Laryngeal dystonia (LD) is a focal dystonia affecting laryngeal muscles, causing involuntary spasms that impair speech production. Recent research demonstrated that non-invasive vibrotactile stimulation (VTS) of the laryngeal area can provide acute symptom relief in up to 57% of patients, with improvements in voice quality and reductions in perceived speech effort lasting from minutes to several days. However, the neural mechanisms underlying this therapeutic effect and the factors determining individual treatment response remain incompletely understood. The objective is to evaluate the acute effects of VTS on voice and speech parameters in participants with LD while characterizing associated changes in brain resting-state networks using magnetic resonance imaging (MRI).

Key Dates

Start date
Jan 14, 2026
Status verified
Mar 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Laryngeal Dystonia Patients
  • Active Comparator: Healthy Controls

Primary Outcome Measure

Change in Brain Resting-State Functional Connectivity due to VTS [ Time Frame: Hour 2.5 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55455-

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University of Minnesota· Minneapolis, MN

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