Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Dana-Farber Cancer Institute
Study ID
NCT07442578
Status
Active Not Recruiting

Conditions

  • Anthracycline-induced Cardiotoxicity
  • Cardiotoxicity
  • Cardiovascular Diseases
  • Childhood Cancer Survivors

Eligibility Criteria

Sex
ALL
Age
18 Years - 39 Years
Healthy Volunteers
Not accepted

Interventions

  • HIIT Exercise Program — BEHAVIORAL
    Exercise program with stationary bike via the Zoom platform.
  • MICT Exercise Program — BEHAVIORAL
    Exercise program with stationary bike via the Zoom platform.

Study Details

This trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines.

Key Dates

Start date
Mar 4, 2026
Status verified
Mar 2026
Primary completion
Mar 4, 2027
Completion
Mar 4, 2028

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: High Intensity Interval Training (HIIT)
    Participants will be randomly assigned to the HIIT exercise group and receive: * Baseline visit and surveys * 3x weekly for 16 week home-based virtually supervised High-Intensity Interval Training * Post-intervention visit and surveys
  • Active Comparator: Moderate Intensity Continuous Training (MICT)
    Participants will be randomly assigned to the MICT exercise group and receive: * Baseline visit and surveys * 3x weekly for 16 week home-based virtually supervised Moderate Intensity Continuous Training * Post-intervention visit and surveys

Primary Outcome Measure

Change in average E/e' ratio [ Time Frame: Baseline (Week 0) and post-intervention (Week 17) ]

Locations (1)

FacilityCityStateZIPSite coordinators
Dana-Farber Cancer InstituteBostonMassachusetts02215-

Find similar trials in Boston, MA

By research site
Dana-Farber Cancer Institute· Boston, MA

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