Inherited and Environmental Risks Acting on Body Weight

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT07430852
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
20 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Diet modification — BEHAVIORAL
    Participants will be provided all meals for a 14-day period. For 7 of the days, meals will be 150% of estimated daily caloric needs and for the other 7 days, meals will be low in calories, consistent with recommendations for weight loss.

Study Details

The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.

Key Dates

Start date
Sep 1, 2026
Status verified
Feb 2026
Primary completion
Nov 1, 2029
Completion
Apr 30, 2030

Study Design

Enrollment
110 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • No Intervention: Study 1, A co-twin control study of habitual diet
    Monozygotic twin pairs with differential habitual diet practices will undergo measurements including body composition, and MRI measures of hepatic adiposity and neuroinflammation.
  • Experimental: Study 2, A twin study of controlled diet
    Monozygotic twin pairs will be provided an assigned diet for 14-days.

Primary Outcome Measure

Study 1: Hypothalamic Gliosis [ Time Frame: at enrollment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WashingtonSeattleWashington98109
INTERACT Study
[email protected]
206-616-6360

Find similar trials in Seattle, WA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of Washington· Seattle, WA

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