Snacking Effects on the Brain Response to Foods and Satiety During Dieting

Conditions

• Overweight/Obesity

Eligibility Criteria

Sex

ALL

Age

25 Years - 45 Years

Healthy Volunteers

Not accepted

Interventions

• Snack Type 1: Walnuts — OTHER
  Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team.
• Snack Type 2: Pretzels — OTHER
  Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team.

Study Details

This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.

Key Dates

Start date

Mar 5, 2026

Status verified

Mar 2026

Primary completion

Mar 31, 2028

Completion

Mar 31, 2028

Study Design

Enrollment

70 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Experimental: Snack Type 1: Walnuts
  Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).
• Active Comparator: Snack Type 2: Pretzels
  Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).

Primary Outcome Measure

Percent change in Blood Oxygen Level Dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging [ Time Frame: Baseline, 12 weeks ]

Central Contacts

• Allison Hild, BS
  3037249024
  [email protected]
• Kristina T Legget, PhD
  303-724-5809
  [email protected]

Locations (1)

Find similar trials in Aurora, CO

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