Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

Part of paid clinical trials in Aurora, Colorado.

Sponsor
VA Office of Research and Development
Study ID
NCT06627569
Status
Not Yet Recruiting

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Conditions

  • Overweight/Obesity
  • Stress

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — BEHAVIORAL
    12 weeks of aerobic exercise, with 4 sessions per week.

Study Details

The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

Key Dates

Start date
Jun 1, 2026
Status verified
May 2026
Primary completion
Aug 30, 2030
Completion
Aug 30, 2030

Study Design

Enrollment
132 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Exercise
    Participants will complete 4 aerobic exercise training sessions per week for 12 weeks. The exercise program will begin at 15 minutes per session and duration will be gradually increased by 5 minutes each week until participants reach 30 minutes per session (with 5 min warm-up and cool-down). Exercise will be performed at a "moderate" intensity, which will be about 60-70% of your predicted maximal level. Participants will meet with study personnel once per week.
  • No Intervention: Usual activity
    Participants will keep doing what they usually do for the 12-week intervention period. They will be asked not to change their usual physical activity levels during this period. They will meet with study personnel once per week

Primary Outcome Measure

Percent change in blood oxygen level dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging (fMRI) [ Time Frame: Baseline, 12 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Rocky Mountain Regional VA Medical Center, Aurora, COAuroraColorado80045-7211
Kristina T Legget, PhD
[email protected]
(720) 724-5809
Kristina T. Legget, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Rocky Mountain Regional VA Medical Center, Aurora, CO· Aurora, CO

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