Radiotherapy for Refractory Hidradenitis Suppurativa

Part of paid clinical trials in Cherry Hill, New Jersey.

Sponsor
Thomas Jefferson University
Study ID
NCT07414550
Status
Recruiting
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Conditions

  • Hidradenitis Suppurativa (HS)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Radiated axilla — RADIATION
    Intervention: Radiation Total dose: 45 Gy Fractionation: 3 Gy per fraction Schedule: Three fractions per week for approximately five weeks

Study Details

The goal of this clinical trial is to learn if high-dose radiotherapy can provide sustained disease relief in moderate to severe, treatment resistant Hidradenitis suppurativa patients; could include any of the following: any sex/gender, and those greater then 18 years old. The main question\[s\] it aims to answer are: Outcome measure 1: Will radiotherapy change the number of inflammatory nodules, abscesses, and draining sinus tracts in the treated axilla compared with the untreated axilla? Outcome measure 2: Will radiotherapy positively change a patient's quality of life, pain levels and symptom burden? Participants will receive radiotherapy to one axilla affected by hidradenitis suppurativa. The contralateral axilla will not receive radiotherapy and will continue receiving the standard treatment regimen. Participants will... * Attend a baseline dermatology skin evaluation, complete multiple surveys and an optional participation in a biopsy * Attend multiple radiation sessions over 5 weeks * Attend 2 follow up visits with dermatology for skin evaluation, complete follow up surveys, and an optional biopsy.

Key Dates

Start date
May 1, 2026
Status verified
May 2026
Primary completion
May 1, 2027
Completion
Mar 1, 2028

Study Design

Enrollment
10 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Radiation axilla
    Participants will receive radiotherapy to one axilla affected by hidradenitis suppurativa.
  • No Intervention: Non-radiated Axilla
    The contralateral axilla will not receive radiotherapy and will continue on the current standard of care.

Primary Outcome Measure

Change in HS Disease Activity [ Time Frame: Baseline (within 7 days prior to first radiotherapy treatment) to 12 weeks after completion of radiotherapy ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Jefferson Cherry Hill - Radiation OncologyCherry HillNew Jersey08003
Gregory Alexander, MD
[email protected]
856-922-4800
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107
Sherry Yang, MD
[email protected]
215-955-6680

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Jefferson Cherry Hill - Radiation Oncology· Cherry Hill, NJThomas Jefferson University· Philadelphia, PA

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