Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Incyte Corporation
Study ID
NCT07213973
Phase
PHASE2
Status
Recruiting
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Conditions

  • Hidradenitis Suppurativa (HS)

Eligibility Criteria

Sex
ALL
Age
12 Years - 17 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to evaluate the pharmacokinetics, safety, and efficacy of povorcitinib in adolescent participants with moderate to severe hidradenitis suppurativa over a 54-week open-label treatment period.

Key Dates

Start date
Feb 2, 2026
Status verified
May 2026
Primary completion
Mar 25, 2028
Completion
Mar 25, 2028

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Povorcitinib Dose A
    Participants will receive povorcitinib dose A for 54 weeks.
  • Experimental: Povorcitinib Dose B
    Participants will receive povorcitinib dose B for 54 weeks.

Primary Outcome Measure

Proportion of participants with Treatment-Emergent Adverse Events (TEAEs) [ Time Frame: Baseline through Week 54 ]

Central Contacts

Locations (25)

FacilityCityStateZIPSite coordinators
University of Alabama At BirminghamBirminghamAlabama35233-
Medical Dermatology Specialists PhoenixPhoenixArizona85006-
Saguaro DermatologyPhoenixArizona85008-
Uconn HealthFarmingtonConnecticut06030-
Skin Research of South Florida, LlcMiamiFlorida33173-
University of Miami Miller School of MedicineMiamiFlorida33136-
Trueblue Clinical ResearchTampaFlorida33607-
Advanced Medical Research PcSandy SpringsGeorgia30328-
Endeavor Health Medical GroupSkokieIllinois60077-
Dermatology Skin Cancer Center LeawoodLeawoodKansas66211-
Equity MedicalBowling GreenKentucky42104-
Johns Hopkins Univ Schl of MedicineBaltimoreMaryland21205-
Skin Oasis DermatologyGambrillsMaryland21054-
Boston Childrens HospitalBostonMassachusetts02115-
Oakland Hills Dermatology PcAuburn HillsMichigan48326-
Wayne State University Physician Group DermatologyDetroitMichigan48201-
Revival Research Institute, Llc TroyTroyMichigan48084-
Washington UniversitySt LouisMissouri63110-
Boeson Research Missoula 2825 Fort Missoula RdMissoulaMontana59804-
University of New Mexico HospitalAlbuquerqueNew Mexico87102-
Geisinger Medical CenterDanvillePennsylvania17822-
Bellaire Dermatology Associates BdaBellaireTexas77401-
Texas Dermatology Research CenterDallasTexas75246-
3A Research Llc West LocationEl PasoTexas79902-
Jordan Valley Dermatology CenterSouth JordanUtah84095-

Find similar trials in Birmingham, AL

By research site
University of Alabama At Birmingham· Birmingham, ALMedical Dermatology Specialists Phoenix· Phoenix, AZSaguaro Dermatology· Phoenix, AZUconn Health· Farmington, CTSkin Research of South Florida, Llc· Miami, FLUniversity of Miami Miller School of Medicine· Miami, FL

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