Reversal of Spinal Anesthesia Residual Motor Block Via Intrathecal Catheter

Conditions

• Joint Replacement Surgery

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Not accepted

Interventions

• Normal Saline 10 mL Injection — DRUG
  Patients randomized to this arm will have saline administration via intrathecal catheter post-op prior to removal

Study Details

The purpose of this study is to determine the feasibility of administering a predetermined amount of normal saline into the intrathecal or subarachnoid space via a small spinal catheter to reduce or eliminate the effects of previously injected spinal anesthetic following lower extremity orthopedic surgery.

Key Dates

Start date

Mar 19, 2026

Status verified

Apr 2026

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

20 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• No Intervention: Control
  Patients randomized to the control group will receive a combined spinal intrathecal catheter and the same dosing of spinal medications. All aspects of care and monitoring will be the same as non-study patients. The control group will not receive a dose of intrathecal saline post-op
• Experimental: Saline administered via the intrathecal catheter
  Patients randomized to the Intervention group will be administered 10ml of sterile normal saline via the intrathecal catheter post-op prior to catheter removal.

Primary Outcome Measure

Time to residual motor blockade reversal [ Time Frame: Initiation of spinal anesthetic to reversal, up to sixty minutes after removal of catheter. ]

Central Contacts

• Anna Fratello
  617-632-8058
  [email protected]

Locations (1)

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