Molecular Indicators of Systematic Fitness

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
VO Health, Inc.
Study ID
NCT07393841
Status
Recruiting
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Conditions

  • Aging
  • Athlete
  • Exercise Physiology
  • Fitness Testing
  • Healthy Adult
  • Human Performance

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • There is no intervention. — OTHER
    The investigators are not administering an intervention for this study. To opportunistically capture prospective data, the investigators give participants the option for re-testing after a period of time where participants are undergoing a self-directed intervention (i.e., no influence of the research staff), such as training for a marathon or other fitness event.

Study Details

The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are: 1. Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak? 2. How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles? 3. Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)? 4. What is the analytic reliability of the predictor biomarkers?

Key Dates

Start date
Jan 5, 2026
Status verified
Feb 2026
Primary completion
Jan 5, 2028
Completion
May 10, 2028

Study Design

Enrollment
250 participants (estimated)

Primary Outcome Measure

A multi-analyte biomarker panel to predict maximal aerobic capacity [ Time Frame: Day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
VO Health, Inc.New HavenConnecticut06510
Brooks P Leitner, MD, PhD
[email protected]
443-474-7206
Sean P Langan, PhD
[email protected]
Brooks P Leitner, MD, PhD (PRINCIPAL_INVESTIGATOR)
Sean P Langan, PhD (SUB_INVESTIGATOR)

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