A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Conditions

• Obesity
• Overweight
• Sleep Apnea, Obstructive

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Eloralintide — DRUG
  Administered SC
• Placebo — DRUG
  Administered SC

Study Details

The purpose of the studies is to evaluate the efficacy and safety of eloralintide in participants with moderate-to-severe obstructive sleep apnea and obesity or overweight. YDAO is a master protocol designed to support two independent studies: YSA1 and YSA2. Study YSA1 will include participants who are unable or unwilling to use Positive Airway Pressure (PAP) therapy and study YSA2 will include participants who are on PAP therapy for at least 3 months at time of screening and plan to continue PAP therapy during the study. Participants will be assigned to the Intervention-Specific Appendix (ISA) that reflects their current PAP usage. Participation in the study will last about 76 weeks.

Key Dates

Start date

Feb 10, 2026

Status verified

Jun 2026

Primary completion

Mar 31, 2028

Completion

Apr 30, 2028

Study Design

Enrollment

800 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Eloralintide (YSA1)
  Participants will receive eloralintide subcutaneously (SC)
• Placebo Comparator: Placebo (YSA1)
  Participants will receive placebo SC
• Experimental: Eloralintide (YSA2)
  Participants will receive eloralintide SC
• Placebo Comparator: Placebo (YSA2)
  Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]

Central Contacts

• Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  1-317-615-4559
  [email protected]
• Physicians interested in becoming principal investigators please contact
  [email protected]

Locations (23)

Find similar trials in Cullman, AL

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