A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT07357415
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to investigate the efficacy and safety of different retatrutide dose escalation schemes in participants without type 2 diabetes who have obesity or overweight. Participation in the study will last about 113 weeks.

Key Dates

Start date
Jan 24, 2026
Status verified
Jun 2026
Primary completion
Oct 31, 2028
Completion
Nov 30, 2028

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose Escalation 1
    Participants will receive retatrutide subcutaneously (SC)
  • Experimental: Retatrutide Dose Escalation 2
    Participants will receive retatrutide SC
  • Experimental: Retatrutide Dose Escalation 3
    Participants will receive retatrutide SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 104 ]

Locations (20)

FacilityCityStateZIPSite coordinators
Arizona Research CenterPhoenixArizona85053-
Care Access - Huntington BeachHuntington BeachCalifornia92648-
Los Angeles Institute for Metabolic ResearchLos AngelesCalifornia90015-
New Horizon Research CenterMiamiFlorida33165-
Encore Medical Research - WestonWestonFlorida33331-
Pacific Diabetes & Endocrine CenterHonoluluHawaii96817-
Monroe Biomedical Research - LouisvilleLouisvilleKentucky40213-
Brigham and Women's Hospital Diabetes ProgramBostonMassachusetts02115-
Great Lakes Research Group, Inc.Bay CityMichigan48706-
NYC Research INCLong Island CityNew York11106-
Weill Cornell Medical CollegeNew YorkNew York10021-
Care Access - RaleighRaleighNorth Carolina27607-
New Phase Research and DevelopmentKnoxvilleTennessee37909-
Cedar Health ResearchDallasTexas75251-
Cedar Health Research - Texas Native HealthDallasTexas75235-
Velocity Clinical Research, DallasDallasTexas75230-
Cedar Health Research - Fort WorthFort WorthTexas76132-
Advanced Research InstituteOgdenUtah84405-
Dominion Medical Associates, Inc.RichmondVirginia23219-
CAMC Institute for Academic MedicineCharlestonWest Virginia25304-

Find similar trials in Phoenix, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Arizona Research Center· Phoenix, AZCare Access - Huntington Beach· Huntington Beach, CALos Angeles Institute for Metabolic Research· Los Angeles, CANew Horizon Research Center· Miami, FLEncore Medical Research - Weston· Weston, FLPacific Diabetes & Endocrine Center· Honolulu, HI

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