Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Part of paid clinical trials in Mobile, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT07353931
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Eloralintide — DRUG
    Administered SC
  • Placebo — DRUG
    Placebo administered SC

Study Details

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Key Dates

Start date
Feb 9, 2026
Status verified
Jun 2026
Primary completion
Mar 31, 2028
Completion
May 31, 2028

Study Design

Enrollment
900 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Eloralintide (YOA1)
    Participants will receive eloralintide subcutaneously (SC)
  • Placebo Comparator: Placebo (YOA1)
    Participants will receive placebo SC
  • Experimental: Eloralintide (YOA2)
    Participants will receive eloralintide SC
  • Placebo Comparator: Placebo (YOA2)
    Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 64 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (37)

FacilityCityStateZIPSite coordinators
AMR ClinicalMobileAlabama36608
251-414-1984
Harry Studdard (PRINCIPAL_INVESTIGATOR)
Care Access - 801 South Power Road, MesaMesaArizona85206
877-791-0656
Michael Waters (PRINCIPAL_INVESTIGATOR)
Elite Pain and Spine Institute - South Crimson RoadMesaArizona85209
Zeeshan Malik (PRINCIPAL_INVESTIGATOR)
Tucson Orthopaedic Institute - North Wyatt DriveTucsonArizona85712
520-404-0276
Nebojsa Skrepnik (PRINCIPAL_INVESTIGATOR)
Ark Clinical Research - Fountain ValleyFountain ValleyCalifornia92708
714-988-2021
Mark Leibowitz (PRINCIPAL_INVESTIGATOR)
Wolverine Clinical TrialsSanta AnaCalifornia92706
714-617-2426
Behnam Khaleghi (PRINCIPAL_INVESTIGATOR)
Encompass Clinical ResearchSpring ValleyCalifornia91978
619-660-9068
Hanid Audish (PRINCIPAL_INVESTIGATOR)
Diablo Clinical Research, Inc.Walnut CreekCalifornia94598
925-930-7267
Helen Stacey (PRINCIPAL_INVESTIGATOR)
Westside Center for Clinical ResearchJacksonvilleFlorida32205
904-693-1490
Matthew Braddock (PRINCIPAL_INVESTIGATOR)
Care Access - St. PetersburgSt. PetersburgFlorida33710
877-791-0656
Gigi Lefebvre (PRINCIPAL_INVESTIGATOR)
Conquest ResearchWinter ParkFlorida32789
407-916-0060
Anand Patel (PRINCIPAL_INVESTIGATOR)
Orita Clinical ResearchDecaturGeorgia30034
Ahmad Jingo (PRINCIPAL_INVESTIGATOR)
Medical Research PartnersAmmonIdaho83406
208-681-9070
Joseph Moore (PRINCIPAL_INVESTIGATOR)
Great Lakes Clinical Trials - RavenswoodChicagoIllinois60640
773-275-3500
Manish Jain (PRINCIPAL_INVESTIGATOR)
Qualmedica Research, LLCEvansvilleIndiana47715
812-205-2475
Moges Sisay (PRINCIPAL_INVESTIGATOR)
AMR ClinicalNewtonKansas67114
316-804-7304
Troy Holdeman (PRINCIPAL_INVESTIGATOR)
Monroe Biomedical Research - LouisvilleLouisvilleKentucky40213
502-515-5672
Harold Bays (PRINCIPAL_INVESTIGATOR)
Skylight Health Research - BurlingtonBurlingtonMassachusetts01803
781-653-4281
Timothy McAlindon (PRINCIPAL_INVESTIGATOR)
Care Access - QuincyQuincyMassachusetts02169
877-791-0656
Chih Chao Yang (PRINCIPAL_INVESTIGATOR)
Ellipsis Research Group - Brooklyn - 7th StreetBrooklynNew York11215
347-422-0317
Jorge Serje (PRINCIPAL_INVESTIGATOR)
Rochester Clinical Research - BuffaloBuffaloNew York14127
Rajiv Jain (PRINCIPAL_INVESTIGATOR)
NYC Research INCLong Island CityNew York11106
516-574-9232
Anastasios Manessis (PRINCIPAL_INVESTIGATOR)
Rochester Clinical Research, LLCRochesterNew York14609
585-288-0890
Patrick Connors (PRINCIPAL_INVESTIGATOR)
Central States ResearchTulsaOklahoma74136
918-645-5400
Sarah Land (PRINCIPAL_INVESTIGATOR)
Heritage Valley Multispecialty Group, IncBeaverPennsylvania15009
724-770-0935
Michael Oliver (PRINCIPAL_INVESTIGATOR)
Keystone Clinical StudiesPlymouth MeetingPennsylvania19462
Cameron Olezene (PRINCIPAL_INVESTIGATOR)
JCCT - Juno Bellaire SiteBellaireTexas77401
713-779-5494
Rocio Harbison (PRINCIPAL_INVESTIGATOR)
Epic Medical Research - DeSotoDeSotoTexas75115
197-277-7695
HARESH BOGHARA (PRINCIPAL_INVESTIGATOR)
Valley Institute of Research - Fort WorthFort WorthTexas76164
817-625-7733
Alex Guevara (PRINCIPAL_INVESTIGATOR)
Care Access - HoustonHoustonTexas77054
877-791-0656
Ali Bajwa (PRINCIPAL_INVESTIGATOR)
Endeavor Clinical TrialsSan AntonioTexas78240
518-428-6859
Nitendra Agarwal (PRINCIPAL_INVESTIGATOR)
VIP TrialsSan AntonioTexas78230
210-569-2672
Juan Garza (PRINCIPAL_INVESTIGATOR)
Consano Clinical Research, LLCShavano ParkTexas78231
210-545-4900
Michelle Welch (PRINCIPAL_INVESTIGATOR)
Texas Valley Clinical ResearchWeslacoTexas78596
956-431-8090
Eduardo Luna (PRINCIPAL_INVESTIGATOR)
AMR ClinicalSouth JordanUtah84095
Curtis Andrews (PRINCIPAL_INVESTIGATOR)
Charlottesville Medical ResearchCharlottesvilleVirginia22911
434-817-2442
James Clark (PRINCIPAL_INVESTIGATOR)
Paramount Clinical Research - Data Point Clinical ResearchKirklandWashington98034
425-577-1107
Javier Nazar (PRINCIPAL_INVESTIGATOR)

Find similar trials in Mobile, AL

By condition
Osteoarthritis (other)
By specialty
OrthopedicsMusculoskeletal disorders
By research site
AMR Clinical· Mobile, ALCare Access - 801 South Power Road, Mesa· Mesa, AZElite Pain and Spine Institute - South Crimson Road· Mesa, AZTucson Orthopaedic Institute - North Wyatt Drive· Tucson, AZArk Clinical Research - Fountain Valley· Fountain Valley, CAWolverine Clinical Trials· Santa Ana, CA

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