Does Vitamin C Increase the Body Heat Generated By The Nervous System?

Part of paid clinical trials in Fort Collins, Colorado.

Sponsor
Colorado State University
Study ID
NCT07341308
Status
Recruiting
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Conditions

  • Metabolism Changes
  • Vitamin D

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Vitamin C — OTHER
    Vitamin C will be co-infused with isoproterenol

Study Details

The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are: 1. By how much does body temperature increase during stimulation of beta-adrenergic receptors when vitamin C is given. 2. By how much does circulating vitamin D concentration increase during stimulation of beta-adrenergic receptors when vitamin C is given. Participants will will be asked to: * undergo measures of body temperature * have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.

Key Dates

Start date
Mar 17, 2025
Status verified
Jan 2026
Primary completion
Jun 8, 2026
Completion
Dec 8, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • No Intervention: Response to beta-adrenergic stimulation without vitamin C
    Isoproterenol will be infused with saline only
  • Experimental: Adding vitamin C to beta-adrenergic receptor stilmulation
    Isoproterenol will be infused with vitamin C

Primary Outcome Measure

Body Temperature [ Time Frame: Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Colorado State UniversityFort CollinsColorado80523
Christopher Bell, PhD
[email protected]
9704917522
Taylor Ewell, MS
[email protected]
9704913495

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By research site
Colorado State University· Fort Collins, CO

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