Pistachio Snacking and Metabolic Flexibility

Part of paid clinical trials in Columbia, South Carolina.

Sponsor
University of South Carolina
Study ID
NCT07340125
Status
Recruiting
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Conditions

  • Healthy Participants
  • Obese But Otherwise Healthy Participants
  • Obese Patients (BMI ≥ 30 kg/m²)
  • Overweight (BMI > 25)
  • Overweight or Obese
  • Physically Inactive
  • Poor Sleep Quality

Eligibility Criteria

Sex
ALL
Age
25 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Pistachio — OTHER
    Roasted, lightly salted, pistachio kernels (no shell)

Study Details

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Key Dates

Start date
Sep 1, 2025
Status verified
Jan 2026
Primary completion
Aug 1, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Pistachio
    Four days of pistachio snacking, to be consumed mid-morning (1oz; 9-11am), mid-afternoon (1oz; 2-4pm), and pre-sleep (0.5 oz; within 1hr of bedtime), while otherwise maintaining normal dietary habits. An addition snack will be consumed post-exercise (0.5oz).
  • No Intervention: Control
    Maintain normal dietary habits for four days.

Primary Outcome Measure

resting metabolism [ Time Frame: Day 0 and Day 5 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Public Health Research Center: Clinical Exercise Research CenterColumbiaSouth Carolina29208-

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Public Health Research Center: Clinical Exercise Research Center· Columbia, SC

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