Emotional Well-being and Measures of Healthy Aging

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT07334106
Status
Recruiting
Apply to this trial

Conditions

  • Aging
  • Aging Well
  • Aging, Biological
  • Aging, Healthy

Eligibility Criteria

Sex
ALL
Age
40 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Positive Emotion Skills Intervention — BEHAVIORAL
    Skills include positive events, capitalizing, gratitude, mindfulness, positive reappraisal, personal strengths, achievable goals, and self-compassion. The skills will be delivered over approximately 6 weeks, and individuals can participate from any device and location with internet access. A week will consist of 1-2 days of didactic material and 5-6 days of real-life skills practice and reporting. Participants cannot skip ahead and can only progress to the next lesson if they have completed the current one, but they can return to old lessons or exercises if they wish to.

Study Details

This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and convenient. Our main aims are: Aim 1: To explore the effects of PARK on psychological well-being (e.g., depression, anxiety, positive affect). Aim 2: To explore the effects of PARK on biological age as defined by DNA methylation (DNAm) GrimAge and electrocardiogram-age (ECG-age), as well as physiological well-being in adults (e.g., cardiovascular, endocrine, musculoskeletal functioning, etc.).

Key Dates

Start date
Sep 1, 2025
Status verified
Jan 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Positive Emotion Skills Intervention
    Participants will receive the 6-week online intervention, PARK (Positive Affect Regulation sKills Course).
  • No Intervention: Waitlist Control
    The waitlist control condition will receive usual care in the Human Longevity Lab, which consists of a feedback report on biological age and lifestyle counseling from a clinical provider at the end of the study period. Control condition participants will have the option to gain access to the PARK platform and learn positive emotion skills after their study participation is completed at the end of 12 months.

Primary Outcome Measure

Patient-Reported Outcomes Measurement Information System (PROMIS) Positive Affect (v1.0) and PROMIS Meaning and Purpose (v1.0) [ Time Frame: Baseline, 3 months, 6 months, 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Potocsnak Human Longevity LabChicagoIllinois60611
Chelsea Brown
[email protected]
312-503-3712

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By research site
Potocsnak Human Longevity Lab· Chicago, IL

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