Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT07325175
Status
Recruiting
Apply to this trial

Conditions

  • Deep Brain Stimulation
  • Dystonia
  • Motor Development
  • Pediatric

Eligibility Criteria

Sex
ALL
Age
6 Years - 21 Years
Healthy Volunteers
Accepted

Interventions

  • DBS — DEVICE
    Subjects with DBS will complete protocol with and without active stimulation

Study Details

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

Key Dates

Start date
Jan 1, 2024
Status verified
May 2025
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: DBS
    Patients with DBS will complete neurophysiological recordings with DBS on and off

Primary Outcome Measure

Longitudinal change in Motor Network Aperiodic Activity [ Time Frame: -Baseline -Through study completion, an average of 2 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's Hospital Medical CenterCincinnatiOhio45229
Karlee Migneault
[email protected]
513-636-4200
Travis Larsh, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Cincinnati, OH

By research site
Cincinnati Children's Hospital Medical Center· Cincinnati, OH

Related Studies