Methylphenidate and Response to Alcohol Cues

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT07306078
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 25 Years
Healthy Volunteers
Accepted

Interventions

  • Methylphenidate Pill — DRUG
    Encapsulated methylphenidate
  • Placebo Pill — OTHER
    Encapsulated placebo

Study Details

The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues. The study will observe the effects of methylphenidate or a placebo on neural and craving responses to alcohol cues through fMRI and behavioral testing. Participants will be involved in one remote and two in-person sessions.

Key Dates

Start date
May 31, 2026
Status verified
Apr 2025
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Crossover 1: methylphenidate, placebo
    methylphenidate (single dose, oral, 20 mg, immediate release) followed by placebo (single dose, oral)
  • Experimental: Crossover 2: placebo, methylphenidate
    placebo (single dose, oral) followed by methylphenidate (single dose, oral, 20 mg, immediate release)

Primary Outcome Measure

Neural responses to cues [ Time Frame: 15 minutes ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of FloridaGainesvilleFlorida32610
Amanda Elton, PhD
[email protected]
352-294-4927

Find similar trials in Gainesville, FL

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
University of Florida· Gainesville, FL

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