A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039)

Part of paid clinical trials in Tempe, Arizona.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07300280
Phase
PHASE1
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • MK-0616A — DRUG
    Enlicitide/rosuvastatin fixed dose combination (FDC) or enlicitide/rosuvastatin FDC formulation B oral tablets
  • Enlicitide — DRUG
    Oral tablet
  • Rosuvastatin — DRUG
    Oral tablet

Study Details

This goal of this trial is to learn about two medicines, enlicitide and rosuvastatin, in healthy people. Researchers will compare the amounts of enlicitide and rosuvastatin in a person's body over time, when they are given as separate medicines and when they are combined into one tablet.

Key Dates

Start date
Dec 29, 2025
Status verified
Jun 2026
Primary completion
Oct 14, 2026
Completion
Oct 21, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Enlicitide + Rosuvastatin Part 1
    Participants in Part 1 will receive a single dose of enlicitide tablet coadministered with a single dose of rosuvastatin tablet
  • Experimental: MK-0616A Part 1
    Participants in Part 1 will receive a single dose of MK-0616A
  • Experimental: Enlicitide + Rosuvastatin Part 2
    Participants in Part 2 will receive a single dose of enlicitide tablet coadministered with a single dose of rosuvastatin tablet
  • Experimental: MK-0616A Part 2
    Participants in Part 2 will receive a single dose of MK-0616A formulation B

Primary Outcome Measure

Area Under the Concentration-Time Curve from Time 0 to Infinity (AUC0-Inf) of Enlicitide [ Time Frame: Pre dose and at designated time points up to 168 hours post dose ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Celerion ( Site 0001)TempeArizona85283
Study Coordinator
888-577-8839

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By research site
Celerion· Tempe, AZ

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