Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics

Conditions

• Periodontitis, Diabetes Mellitus Type 2

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• local antibiotic application of topical minocycline — DRUG
  Scaling and Root planing + local application of Arestin ( Minocycline microsphere)
• Scaling and Root Planing — PROCEDURE
  Only scaling and root planing

Study Details

Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.

Key Dates

Start date

Feb 6, 2026

Status verified

Feb 2026

Primary completion

Jun 30, 2027

Completion

Jun 30, 2028

Study Design

Enrollment

42 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Test Group
  Minocycline microspheres (Arestin®) / (4 mg per cartridge) prefilled delivery syringe / Arestin will be placed in the pocket only one time after scaling and root planing.
• Active Comparator: Control Group
  Scaling and Root Planing Alone

Primary Outcome Measure

Pocket Closure [ Time Frame: Baseline, 3 Months, 6 Months ]

Central Contacts

• Gian Pietro Schincaglia, DDS, PhD
  216-368-4412
  [email protected]

Locations (1)

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